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D-amino acid transaminase (DAAT)
- Target
- DAAT
- Molecular classification
- Enzyme, Aminotransferase
01
Overview
D-amino acid transaminase (DAAT) is an enzyme that catalyzes the reversible transfer of amino groups from D-amino acids to 2-oxoglutarate. It is a pyridoxal phosphate (PLP)-dependent enzyme and plays a crucial role in bacterial metabolism, particularly in the synthesis of cell wall components such as D-alanine and D-glutamate. DAATs are potential targets for novel antibacterial agents due to their essential role in bacterial cell wall synthesis and absence in higher eukaryotes.
- Other names
- D-alanine transaminaseD-aspartate transaminaseD-alanine aminotransferaseD-aspartic aminotransferaseD-alanine-D-glutamate transaminaseD-amino acid aminotransferaseD-alanine:2-oxoglutarate aminotransferase
02
Mechanism of action
Suicide inhibition of bacterial cell wall synthesis
03
Biological functions
Amino acid metabolismPeptidoglycan biosynthesisCell wall synthesisCatalysis
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects in commensal bacteria
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