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Target intelligence / Profile preview
Rhesus blood group D antigen (RhD)
- Target
- RhD
- Molecular classification
- Transmembrane protein, Red blood cell antigen
01
Overview
The Rhesus blood group D antigen (RhD antigen) is a protein found on the surface of red blood cells. It is the most clinically significant antigen in the Rh blood group system. The presence or absence of this antigen determines an individual's Rh status (positive or negative). It plays a role in maintaining the structural integrity of red blood cells and may be involved in ammonium transport. Its primary clinical importance lies in its ability to induce alloimmunization, leading to hemolytic disease of the fetus and newborn (HDFN) and transfusion reactions.
- Other names
- D antigenRh polypeptide 1CD240DCluster of differentiation 240D
02
Mechanism of action
Prevention of RhD alloimmunization
03
Biological functions
Maintains RBC membrane integrityPossible ammonium transporter
04
Disease associations
Hemolytic disease of fetus/newborn (HDFN)Transfusion reactionsRh null syndrome
05
Safety considerations
AlloimmunizationHemolytic transfusion reactionsHemolytic disease of the fetus and newborn
06
Interacting drugs
Anti-D immunoglobulin
07
Biomarkers
RhD blood type (positive or negative)
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