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Target intelligence / Profile preview
D-Mannose 1-Phosphate (Man-1-P)
- Target
- Man-1-P
- Molecular classification
- Monosaccharide phosphate, Metabolite, Glycosylation precursor
01
Overview
D-Mannose 1-phosphate is a phosphorylated monosaccharide that plays a crucial role in carbohydrate metabolism and glycosylation processes. It is formed from mannose-6-phosphate via phosphomannomutase and serves as a key intermediate for the biosynthesis of GDP-mannose, dolichol phosphate mannose (Dol-P-Man), and other essential glycosylation precursors. It is essential for N-glycosylation, O-glycosylation, C-mannosylation, and GPI anchor synthesis.
- Other names
- Mannose-1-phosphateD-Mannoheptulose phosphateCHEBI:35374
02
Mechanism of action
N/A (metabolite, not a drug target directly)
03
Biological functions
Intermediate in fructose and mannose metabolismPrecursor for GDP-mannose biosynthesisPrecursor for Dolichol-P-Mannose (Dol-P-Man) biosynthesisSubstrate for glycosylation reactions
04
Disease associations
Congenital Disorders of Glycosylation (indirectly, via enzyme deficiencies in its metabolic pathway)
05
Safety considerations
Accumulation or deficiency can indicate metabolic disorders
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