Damage-control phosphatase 1 (DCPH1)

Damage-control phosphatase 1 (DCPH1, ARMT1) is a metal-dependent enzyme implicated in maintaining cellular integrity by controlling the accumulation of damaged metabolites, especially fructose phosphates with glycation potential[1][3][7]. Structurally, it belongs to the DUF89 protein family and features a conserved α-β-α core fold with catalytic activity requiring divalent cations such as Co²⁺, Ni²⁺, Mn²⁺, or Mg²⁺[1]. DCPH1 demonstrates phosphatase activity towards multiple substrates, with highest activity against fructose-1-phosphate, a potent glycating agent linked to DNA damage[1][3]. It has also been shown to mediate O-methyltransferase reactions that modify glutamate residues in proteins and may participate in DNA damage response by methylating targets such as PCNA[3]. No direct drug interactions are known, and while disease relevance is suggested by its role in damage control and possible links to anemia and cancer, clinical validation as a drug target or biomarker is lacking[3].

Other names

ARMT1C6orf211Acidic residue methyltransferase 1Protein-glutamate O-methyltransferaseSugar phosphate phosphatase ARMT1UPF0364 protein C6orf211Metal-dependent phosphataseProtein O-Methyltransferase