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Target intelligence / Profile preview
Damaged Gastrointestinal Mucosa (GI Mucosa Damage)
- Target
- GI Mucosa Damage
- Molecular classification
- Tissue Structure, Epithelial Barrier, Mucous Membrane
01
Overview
Damaged gastrointestinal mucosa refers to the compromised integrity of the protective lining of the digestive tract, including the stomach and intestines. This damage can result from various factors such as chemical exposure, physical trauma, biological infections, pharmacological agents, and systemic conditions. The resulting breakdown of the mucosal barrier can lead to increased permeability, inflammation, ulceration, and a range of local and systemic complications. Repair mechanisms include restitution and regeneration, but chronic or repetitive injury can impair these processes and lead to chronic disease states.
- Other names
- Gastrointestinal Mucosal InjuryGI Mucosal DamageLeaky GutIntestinal Barrier DysfunctionGastropathyGastritisErosive Gastritis
02
Mechanism of action
N/A
03
Biological functions
Barrier protectionSecretionAbsorptionImmune defenseTissue repairRestitutionRegeneration
04
Disease associations
Peptic Ulcer DiseaseInflammatory Bowel Disease (IBD)Food AllergiesCeliac DiseaseType 1 Diabetes MellitusSepsisGastrointestinal BleedingMalnutrition
05
Safety considerations
Increased intestinal permeabilitySystemic inflammationRisk of infectionDevelopment of autoimmune diseasesDrug-induced injury
06
Interacting drugs
NSAIDs
3 more in the full profile.
07
Biomarkers
Fecal CalprotectinZonulinIntestinal Fatty Acid Binding Protein (I-FABP)Lipopolysaccharide (LPS)HistamineSerum Amyloid A (SAA)
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