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Target intelligence / Profile preview
Damaged myocardial extracellular matrix (none)
- Target
- none
- Molecular classification
- Other (extracellular matrix), Matrix proteins, Structural proteins
01
Overview
The damaged myocardial extracellular matrix is the altered three-dimensional network of proteins (primarily collagens, fibronectin, laminin, and proteoglycans) surrounding heart muscle cells that has been remodeled following injury such as myocardial infarction. This remodeling involves proteolytic degradation, inflammatory cell infiltration, fibroblast activation, and ultimately fibrosis and scar formation, which preserves structural integrity but impairs normal contractile function. Therapeutic strategies target this matrix to modulate healing, reduce scar burden, and restore cardiac function[1][2][3][4].
- Other names
- Damaged cardiac ECMpost-infarct cardiac ECMscarred cardiac matrixremodeling myocardial ECM
02
Mechanism of action
Physical support for tissue regeneration, Modulation of inflammatory and fibrotic response, Promotion of endogenous cardiac repair
03
Biological functions
Structural supportCell signalingRegulation of cell migrationRepair following injuryFibrosis
04
Disease associations
Cardiovascular diseaseMyocardial infarctionCardiomyopathyHeart failure
05
Safety considerations
Risk of excessive fibrosisimpaired cardiac functionarrhythmiasimmune rejection of biomaterials/scaffolds
06
Interacting drugs
Injectable myocardial matrix hydrogels
3 more in the full profile.
07
Biomarkers
Collagen depositionmatrix metalloproteinase activityscar sizetissue stiffness
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