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DAN domain BMP antagonist family member 5 (DAND5)
- Target
- DAND5
- Molecular classification
- Secreted protein, BMP antagonist, Cysteine knot cytokine family, Developmental regulator, Other
01
Overview
DAN domain BMP antagonist family member 5 (DAND5) is a secreted, cysteine knot-containing protein that functions as a bone morphogenetic protein (BMP) antagonist and also antagonizes NODAL signaling[1]. It plays a critical role during embryonic development by regulating organogenesis, tissue differentiation, and proper left-right body axis patterning[1][2]. DAND5 binds directly to BMP and NODAL proteins, inhibiting their signaling cascades, and is necessary for correct specification of left-right asymmetry in vertebrates[1][2]. Alterations in DAND5 function or expression can lead to congenital disorders such as visceral heterotaxy[1][2]. DAND5 gene fusions have also been observed in certain cancer types, but there are no currently known direct drug interactions or established biomarker roles[3].
- Other names
- DAN domain family member 5CER2CKTSF1B3COCOGREM3SP1Cerl-2FLJ38607DANTECERL2DTECocoCerberus-like protein 2Cysteine knot superfamily 1BMP antagonist 3Gremlin-3CRL2HTX13cerberus 2cerberus-like 2cerberus-like protein 2cerl-2
02
Biological functions
Regulation of morphogen signalingAntagonism of NODAL and BMP4 signalingRegulation of left-right axis patterning in embryogenesisOrganogenesisTissue differentiation
03
Disease associations
Congenital disorders (notably, heterotaxy/visceral heterotaxy)Developmental defectsCancer (through gene fusion events)Other
04
Safety considerations
Potential for disrupted embryonic development when antagonized or knocked outRisk of congenital malformations (heterotaxy, organ mispatterning)
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