Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Danger-Associated Molecular Pattern Molecules (DAMPs)
- Target
- DAMPs
- Molecular classification
- Endogenous Danger Signal, Pattern Recognition Receptor Ligands
01
Overview
Danger-associated molecular pattern molecules (DAMPs), also known as alarmins or danger signals, are endogenous molecules released by stressed, damaged, or dying cells. They alert the body to tissue injury or cellular stress in the absence of infection, triggering sterile inflammation by binding to pattern recognition receptors (PRRs) on immune cells.
- Other names
- AlarminsDanger Signals
02
Mechanism of action
DAMPs bind to pattern recognition receptors (PRRs), such as TLRs and RAGE, activating downstream signaling pathways that initiate an inflammatory response.
03
Biological functions
Induction of Sterile InflammationActivation of Innate ImmunityImmune Cell RecruitmentCytokine ProductionRemoval of Cellular Debris
04
Disease associations
SepsisRheumatoid ArthritisSystemic Lupus ErythematosusOsteoarthritisAtherosclerosisAlzheimer's DiseaseParkinson's DiseaseCancerInflammation
05
Safety considerations
Excessive inflammation leading to tissue damagePotential for autoimmunity
06
Biomarkers
HMGB1S100 proteins (e.g., S100A8/MRP8/calgranulin A and S100A9/MRP14/calgranulin B)
Beyond the preview
Go deeper on Danger-Associated Molecular Pattern Molecules (DAMPs).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Danger-Associated Molecular Pattern Molecules (DAMPs).