DAZ-associated protein 1 (DAZAP1)

DAZ-associated protein 1 (DAZAP1) is a member of the hnRNP family of RNA-binding proteins that is highly conserved across vertebrates[1][2]. DAZAP1 contains two N-terminal RNA recognition motif (RRM) domains and a low-complexity, proline-rich C-terminal domain that is important for splicing regulation and protein-protein interactions[1][2]. It was originally identified as a binding partner for DAZ (deleted in azoospermia), a factor implicated in human male infertility[1]. DAZAP1 shuttles between the nucleus and cytoplasm depending on cell type and external signals[2][3]. Its primary function is in the regulation of alternative splicing for hundreds of endogenous gene transcripts, many of which are involved in cell growth, phosphorylation signaling cascades, and energy metabolism[1][2]. DAZAP1 activity is tightly controlled by phosphorylation via the MEK/Erk pathway, which influences its localization and splicing function[1][2]. Knockout of DAZAP1 in mice leads to developmental arrest, smaller body size, premature death, and spermatogenic failure, underscoring its essential role[1][3]. DAZAP1 is not known to be directly targeted by any approved drugs, and there are no clinical biomarkers or safety concerns associated with targeting DAZAP1, as it is not a conventional therapeutic target[1][2][3].

Other names

DAZAP1Deleted in azoospermia-associated protein 1MGC19907Testicular tissue protein Li 50DAZ associated protein 1DAZAP1_X2