DAZ-associated protein 2 (DAZAP2)

DAZ-associated protein 2 (DAZAP2) is a small (~17 kDa) proline-rich adaptor protein encoded by the DAZAP2 gene on chromosome 12, structurally characterized by a central proline-rich region and SH2/SH3 binding sites[3]. The protein is expressed ubiquitously, with notable function in the cytoplasm and nucleus. DAZAP2 interacts with deleted in azoospermia (DAZ), SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and the E3 ubiquitin ligase SIAH1. It regulates the stability of key signaling proteins (notably the kinase HIPK2), modulates the p53 pathway response to DNA damage, affects stress granule formation, RNA splicing, and is implicated in spermatogenesis[1][2][3][5]. Downregulation of DAZAP2 has been linked to multiple myeloma, and recent research indicates it acts as a pan-coronavirus restriction factor inhibiting viral RNA replication[4]. DAZAP2 is not classified as a classical drug target (such as a receptor or enzyme), but rather as an adaptor protein in key cellular pathways.

Other names

DAZAP2KIAA0058PRTBDeleted in azoospermia-associated protein 2Proline-rich transcript in brain proteinProline-rich transcript in brainBrain-expressed protein

No drugs act on DAZAP2 directly; any mechanisms would be indirect via pathways it regulates.