Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DAZ interacting zinc finger protein 1 (DZIP1)
- Target
- DZIP1
- Molecular classification
- Zinc finger protein, Molecular adapter protein, Transcription regulator
01
Overview
DAZ interacting zinc finger protein 1 (DZIP1) is a protein coding gene located on chromosome 13. It encodes a zinc finger protein essential for cilium assembly and maintenance, acting as a molecular adaptor that recruits protein complexes to the ciliary basal body and centriolar satellites. DZIP1 modulates Hedgehog signaling and is involved in organizing the basal body during spermatogenesis and cardiac development. Recent studies indicate its elevated expression in fibroblasts and cancer cells, where it promotes epithelial-mesenchymal transition (EMT) and tumor stroma formation, especially in colorectal cancer. DZIP1 is thus considered a potential molecular target for therapeutic intervention in cancer and fibrotic disease[1][2][16]
- Other names
- DZIP1DAZ interacting protein 1DZIPDZIPt1KIAA0996
02
Mechanism of action
Hypothetical mechanisms, based on disease models, may involve inhibition of DZIP1-mediated EMT and fibroblast activation in tumor microenvironment
03
Biological functions
Cilium organization and assemblySignal transduction (including Hedgehog signaling pathway modulation)Heart developmentSpermatogenesisEpithelial-mesenchymal transition (EMT) regulationProtein complex localization (to centriolar satellite)
04
Disease associations
Cancer (notably colorectal cancer through EMT and stromal interactions)Spermatogenic failure (male infertility)Mitral valve prolapsePotential role in fibrotic diseases
05
Safety considerations
Safety concerns have not been systematically characterized; potential risks may relate to inhibition of normal ciliary function, fertility, or cardiac development.
06
Interacting drugs
No approved or well-characterized drugs specifically target DZIP1 as of now; research on inhibitors or modulators is experimental
07
Biomarkers
DZIP1 expression may serve as a biomarker for colorectal cancer progression (mesenchymal phenotype, EMT), and possibly spermatogenic failure
Beyond the preview
Go deeper on DAZ interacting zinc finger protein 1 (DZIP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DAZ interacting zinc finger protein 1 (DZIP1).