DDB1- and CUL4-associated factor 10 (DCAF10)

DDB1- and CUL4-associated factor 10 (DCAF10) is a WD repeat domain-containing protein that acts as a substrate receptor within the CUL4–DDB1 E3 ubiquitin ligase complex[1][3]. It is involved in targeting proteins for ubiquitination, a post-translational modification that leads to protein degradation via the ubiquitin–proteasome system[1][3]. DCAF10 plays a regulatory role in apoptosis, particularly by promoting the degradation of antiapoptotic proteins such as MCL1, thus activating caspase-dependent cell death pathways[1]. Downregulation or loss of DCAF10 has been observed in certain cancers, such as lung adenocarcinomas, suggesting its function in tumor suppression or oncogenesis[1]. It is also genetically associated with diseases like limb-girdle muscular dystrophy and corpus luteum cysts[3]. At present, DCAF10 is not considered a direct therapeutic target, and no drugs or biomarkers are reported to interact directly with it.

Other names

WDR32WD repeat-containing protein 32WD repeat domain 32MGC10765FLJ23201