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Target intelligence / Profile preview
DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2)
- Target
- DCAF12L2
- Molecular classification
- Other, WD repeat protein family member, Potential adapter/substrate receptor in cullin-RING E3 ubiquitin ligase complexes
01
Overview
DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2) is a member of the WD repeat protein family, characterized by repeating units facilitating protein-protein interactions and assembly of multiprotein complexes. DCAF12L2 is thought to function as an adapter or substrate recognition component in cullin-RING E3 ubiquitin ligase complexes, specifically the CUL4-DDB1 complex, though its direct biochemical activities and substrates remain uncharacterized. The gene is an intronless retrocopy, is expressed in humans, and is conserved across several mammals. While WD repeat proteins in general are implicated in diverse processes such as cell cycle regulation, signal transduction, and apoptosis, the precise physiological and pathological roles of DCAF12L2 remain unclear, and it is not presently considered a validated therapeutic target[4][6][7].
- Other names
- DCAF12L2WDR40CWD repeat-containing protein 40CDDB1 and CUL4 associated factor 12 like 2DDB1- and CUL4-associated factor 12-like protein 2
02
Mechanism of action
null
03
Biological functions
Protein-protein interactionsPossible involvement in cell cycle progressionPutative role in protein ubiquitination (via CRL4 complex participation)May play a role in signal transduction and gene regulation (generic for WD repeat proteins)
04
Disease associations
Other (no direct, validated connection to major disease mechanisms documented; associations reported in genetic syndromes include cleft palate and ankyloglossia, but function is not established)
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