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Target intelligence / Profile preview
DDB1- and CUL4-associated factor 15
- Molecular classification
- E3 ubiquitin ligase component, Substrate receptor, Adaptor protein
01
Overview
DCAF15 is a substrate receptor component of the cullin-RING E3 ubiquitin ligase complex, specifically associated with the CUL4-DDB1 complex. It acts as an adaptor protein that recognizes specific substrates for ubiquitination and subsequent proteasomal degradation. It is involved in the regulation of cell processes, including cell proliferation, migration, and invasion, and plays a role in natural killer cell activation.
- Other names
- DCAF15C19orf72DDB1 and CUL4 associated factor 15
02
Mechanism of action
Acts as an adaptor to bring E3 ubiquitin ligase complex (CRL4) and specific substrates (e.g., ZEB1, RBM39) together, leading to substrate polyubiquitination and proteasomal degradation. Some small molecules can act as "molecular glues" to redirect DCAF15 to new substrates.
03
Biological functions
E3 ubiquitin ligase activitySubstrate recognitionProtein polyubiquitinationRegulation of natural killer cell functionRegulation of cell proliferationRegulation of cell migrationRegulation of cell invasion
04
Disease associations
Cancer
05
Interacting drugs
Indisulam
1 more in the full profile.
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