DDB1- and CUL4-associated factor 8 (DCAF8)

DDB1- and CUL4-associated factor 8 (DCAF8) is a WD repeat-containing protein that functions as a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex in humans[1][5]. It contains seven WD repeats that form a β-propeller structure, critical for recognition of substrate proteins and interaction with the DDB1 scaffold protein[4]. DCAF8 participates in cellular processes by targeting specific proteins—such as chromatin remodeler LSH and methyltransferase DNMT3A—for ubiquitination and subsequent proteasomal degradation, thus playing essential roles in cell cycle regulation, DNA repair, and epigenetic modification[2][4][6]. Pathogenic mutations in DCAF8 are linked to hereditary motor and sensory neuropathy type 2 (with giant axons and potential cardiomyopathy)[4]. Aberrant DCAF8-mediated degradation has been implicated in cancer, where dysregulation of its substrates affects oncogenesis and genome stability[6]. No drugs are currently known to selectively target DCAF8.

Other names

DCAF8WD repeat-containing protein 42AWDR42AH326FLJ35857GAN2

Ubiquitination and targeted proteasomal degradation of substrate proteins via CUL4-DDB1 E3 ubiquitin ligase complex