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DDB1 and CUL4 associated factor 4 like 2 (DCAF4L2)
- Target
- DCAF4L2
- Molecular classification
- Adapter protein, Component of CUL4-RING E3 ubiquitin ligase complex, WD40 repeat protein
01
Overview
DDB1 and CUL4 associated factor 4 like 2 (DCAF4L2) is a WD40 domain-containing protein believed to function as a substrate identifier (adapter) within the CUL4-RING E3 ubiquitin ligase complex[2][3]. Through its interaction with DDB1, DCAF4L2 helps recruit specific protein substrates for ubiquitination, which marks proteins for degradation or modulates cellular processes such as signal transduction and cell cycle control. While DCAF4L2 itself is not specifically tied to a disease, the broader CUL4-DDB1-DCAF complex is involved in cell cycle regulation, stem cell maintenance, and DNA damage response pathways[1]. DCAF4L2 is closely related to DCAF4 (a known substrate receptor), and belongs to the family of WD40 repeat-containing adapter proteins that diversify the activity of ubiquitin ligase complexes by conferring substrate specificity[2][3].
- Other names
- WDR21C
02
Mechanism of action
No specific drug mechanism for DCAF4L2; generally, related CUL4-DDB1 complexes mediate substrate ubiquitination
03
Biological functions
Protein ubiquitinationSubstrate recruitment for ubiquitin ligase complexRegulation of signal transduction
04
Disease associations
Other (Direct links to specific diseases are not evident in the current search results, but related CUL4-DDB1-DCAF complexes are implicated in cancer and cell cycle disorders)
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