DDRGK domain-containing protein 1 (DDRGK1)

DDRGK domain-containing protein 1 (**DDRGK1**) is a key component of the UFM1 conjugation (ufmylation) system, acting both as a scaffold and a reader for UFM1-modified proteins at the endoplasmic reticulum (ER)[3]. Its PCI domain mediates protein interactions, while an N-terminal signal peptide anchors it to the ER membrane[1][2][3]. DDRGK1 regulates lysosomal function and autophagy, controls the unfolded protein response, and is essential for the proper recycling of ribosomes from the ER. It further modulates NF-κB signaling and affects apoptosis in ER-stressed secretory tissues[3][4]. Loss or dysfunction of DDRGK1 has been implicated in hematopoietic disorders, impaired plasma cell differentiation, specific genetic dysplasias, and intestinal inflammation. Direct pharmacological targeting of DDRGK1 is not established, but its central role in cellular stress responses and immunity highlights its potential as a future therapeutic target.

Other names

C20orf116UFBP1DashurindJ1187M17.3UFM1-binding and PCI domain-containing protein 1SEMDSH