Purine Synthesis Pathway Enzymes

The purine synthesis pathway consists of a series of enzymatic reactions that build the purine ring system, ultimately producing inosine monophosphate (IMP), which serves as the precursor for adenosine monophosphate (AMP) and guanosine monophosphate (GMP). This pathway is essential for nucleotide biosynthesis in all cells. Key enzymes include Glutamine PRPP amidotransferase (GPAT/PurF), GAR synthetase, GAR transformylase, FGAM synthetase, AIR synthetase, PAICS, and ATIC. It is regulated by feedback inhibition of IMP/AMP/GMP and activated by PRPP. Inhibitors are used as immunosuppressants and cancer therapeutics.

Other names

De novo purine biosynthetic pathway enzymes

Inhibition of purine nucleotide synthesis