De Novo Purine Synthesis Pathway

The de novo purine synthesis pathway is a fundamental biochemical process by which cells synthesize purine nucleotides (AMP and GMP) from small, simple precursor molecules. This pathway is essential for the production of nucleotides required for DNA and RNA synthesis, cellular signaling, metabolism, and energy homeostasis. The pathway begins with ribose-5-phosphate and involves a series of enzymatic reactions to form inosine monophosphate (IMP), which is then converted to AMP and GMP. Key enzymes such as PRPP synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, and IMP dehydrogenase are crucial for the pathway's function. The pathway is regulated by feedback inhibition and allosteric modulation. It is a target for anticancer and immunosuppressive drugs.

Other names

Purine BiosynthesisDe Novo Purine Nucleotide Synthesis

Inhibition of enzymes in the purine synthesis pathway, leading to decreased purine nucleotide production.