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Target intelligence / Profile preview
De novo Pyrimidine Biosynthesis Enzymes (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Multifunctional enzyme complex
01
Overview
De novo pyrimidine biosynthesis enzymes are responsible for the synthesis of pyrimidine nucleotides from basic precursors, essential for DNA/RNA synthesis and cell proliferation. The pathway involves key enzymes like CAD complex (CPSII, ATCase, Dihydroorotase), Dihydroorotate dehydrogenase (DHODH), and Uridine monophosphate synthase (UMPS). These enzymes are drug targets for cancer therapy and antimicrobial agents.
- Other names
- Pyrimidine biosynthesis pathway enzymesPyrimidine synthesis enzymesCAD complexDHODHUMPS
02
Mechanism of action
Inhibition of pyrimidine biosynthesis
03
Biological functions
Nucleotide biosynthesisDNA synthesisRNA synthesisCell proliferationMetabolism
04
Disease associations
CancerMetabolic disordersInfection
05
Safety considerations
MyelosuppressionTeratogenicityHepatotoxicity
06
Interacting drugs
Brequinar
3 more in the full profile.
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