DEAD-box helicase 24 (DDX24)

DEAD-box helicase 24 (DDX24) is an ATP-dependent RNA helicase belonging to the DEAD-box protein family, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif and a RecA-like core domain. DDX24 is implicated in diverse cellular processes involving alteration of RNA secondary structure, including pre-mRNA splicing, translation initiation, and assembly of ribonucleoprotein (RNP) complexes. It plays a critical role in cell proliferation, cell cycle regulation, and DNA repair in vascular smooth muscle cells by binding and stabilizing FANCA mRNA. DDX24 also acts as a negative regulator of innate immune signaling by sequestering RNA away from pattern-recognition receptors, and as an inhibitor of TP53 transcriptional activity, influencing cell growth arrest and senescence. Loss of DDX24 disrupts vascular development and leads to embryonic lethality in mouse models, underscoring its essential function. DDX24 has been linked to cancer, vascular malformations, and infection-related processes, making it an emerging, albeit currently undrugged, therapeutic target.

Other names

ATP-dependent RNA helicase DDX24DEAD box protein 24DEAD (Asp-Glu-Ala-Asp) box helicase 24DEAD (Asp-Glu-Ala-Asp) box polypeptide 24DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24S. cerevisiae CHL1-like helicaseDDX24

Not explicitly detailed for drugs, but inhibition of DDX24 would likely impair cell proliferation by causing cell cycle arrest, DNA damage, and impaired RNA metabolism. Targeting DDX24 may modulate innate immune responses or influence p53 pathway activity.