DEAD-box helicase 3 pseudogene 2 (DDX3P2)

DEAD-box helicase 3 pseudogene 2 (DDX3P2) is a pseudogene similar in sequence to functional DEAD-box helicase genes but lacks protein-coding capacity. DEAD-box helicase family genes, such as DDX3X and DDX3Y, are involved in ATP-dependent RNA helicase activity and play roles in RNA metabolism, immune response, and several diseases, including cancers[2][3][1]. However, DDX3P2 itself is a non-functional locus thought to be derived from the DDX3Y or DDX3X genes and does not encode an active enzyme or therapeutic target[2][3]. Context and Clarification: - Pseudogenes such as DDX3P2 generally do not produce functional proteins and are not considered direct therapeutic targets or true receptors, enzymes, transporters, or transcription factors[2][3]. - Functional relevance, disease connection, and druggability apply instead to the canonical protein-coding DDX3Y and DDX3X genes, not to DDX3P2. Drugs, disease associations, and mechanisms of action referenced in the context of DEAD-box helicases or DDX3 should not be mapped to DDX3P2[1][2][3]. If you seek data on functional DEAD-box helicase 3 targets, focus on DDX3Y or DDX3X, not DDX3P2.

Other names

DDX3P2DDX3YP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked pseudogene 2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, pseudogene 2