DEAD-box helicase 41 mRNA 3′ untranslated region (DDX41 mRNA 3′UTR)

The DEAD-box helicase 41 (DDX41) mRNA 3′ untranslated region (3′UTR) is a critical regulatory segment of the DDX41 transcript, which encodes an enzyme essential for pre-mRNA splicing and the sensing of cytosolic DNA via the cGAS-STING pathway (UniProt Q9UJW0). This region contains binding sites for microRNAs and RNA-binding proteins that dictate the stability and translation efficiency of the DDX41 message (PubMed: 26343578). Mutations or dysregulation of DDX41 are strongly associated with predispositions to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), where mutations often lead to loss of function or altered protein levels (PubMed: 25961753). Therapeutic strategies targeting the DDX41 mRNA 3′UTR, such as antisense oligonucleotides (ASOs) or RNA interference (RNAi), are being explored to modulate DDX41 expression in hematologic malignancies and inflammatory disorders. By targeting this specific regulatory region, researchers aim to either degrade the transcript or block the binding of inhibitory factors to restore homeostatic protein levels. The 3′UTR is specifically targeted to avoid interfering with the coding sequence while achieving potent knockdown or regulatory control (PubMed: 33076416).

Other names

DDX41 3′UTRDEAD-box protein 41 mRNA 3′UTRABS mRNA 3′UTR

Antisense-mediated mRNA degradation, RNA interference, and steric hindrance of regulatory elements