DEAD-box helicase 43 pseudogene 2 (DDX43P2)

DEAD-box helicase 43 pseudogene 2 (DDX43P2) is named as a pseudogene related to the protein-coding DEAD-box helicase 43 (DDX43), but there is no evidence that DDX43P2 encodes a functional protein or that it serves as a therapeutic target. Pseudogenes, by definition, are genomic DNA sequences similar to normal genes but are non-functional; they typically arise from the duplication or retrotransposition of functional genes and are generally not translated into proteins. Context and supporting details: - DDX43 (not DDX43P2) is a protein-coding gene known to encode an ATP-dependent RNA and DNA helicase, implicated in several biological functions and considered as a cancer/testis antigen and potential cancer therapy target[1]. - DEAD-box protein family includes enzymes involved in RNA metabolism, but only functional protein-coding members (such as DDX43 itself) are of interest as molecular targets, not their pseudogenes[2]. - No evidence supports the role of DDX43P2 pseudogene in disease, cell signaling, or as a receptor, enzyme, transporter, or any other classical therapeutic target class. If you meant the functional protein DDX43 (also known as HAGE), that is a valid cancer biomarker and potential therapeutic target, but DDX43P2 only annotates its related pseudogene, which is not considered a therapeutic target by itself[1]. There is no information in the current literature or standard gene/protein databases to suggest DDX43P2 encodes a receptor, enzyme, or functional protein, nor any associated drugs, biomarkers, or disease roles. If your intent was to query the functional gene or its encoded protein (DDX43/HAGE), please clarify, as the answer would be different and substantially richer.

Other names

DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 pseudogene 2DDX43P2