DEAD-box helicase 58 (RIG-I)

DDX58, also known as RIG-I, is a cytoplasmic pattern recognition receptor that plays a central role in the innate immune response. It recognizes viral double-stranded RNA with 5' triphosphate ends, activating downstream signaling cascades leading to the production of type I interferons and proinflammatory cytokines. RIG-I is crucial for antiviral defense and is involved in the regulation of inflammation, autophagy, apoptosis, and tumor immune responses. Mutations can lead to excessive interferon pathway activation, and variants are associated with susceptibility to severe influenza infection and autoimmune diseases. High expression levels correlate with prognosis across multiple cancers.

Other names

ATP-dependent RNA helicase DDX58DEAD box protein 58Retinoic acid-inducible gene I proteinAntiviral innate immune response receptor RIG-IRLR1RIGI