DEAH-box helicase 16 (DHX16)

DEAH-box helicase 16 (DHX16) is an ATP-dependent RNA helicase of the DEAH-box family, critical for catalyzing conformational rearrangements during pre-mRNA splicing in the spliceosome[1][3][4]. It functions after the formation of the pre-catalytic spliceosome (complex B), likely facilitating the transition required for the first catalytic step of splicing[1][4]. Loss or mutation of DHX16 results in the accumulation of unspliced transcripts and impaired splicing activity in vitro and in vivo[1]. DHX16 is encoded on chromosome 6p21.3 in the major histocompatibility complex (MHC) region, a locus linked to several malignant and autoimmune diseases[1][3]. The protein is implicated in cell cycle progression, embryogenesis, and innate antiviral immunity through recognition of specific viral RNAs[5]. DHX16’s malfunction is implicated in neurodevelopmental and autoimmune disorders, but it is not currently a direct drug target and no specific drugs or biomarker utilities are described in available sources[4][5].

Other names

DBP2DDX16KIAA0577PRP2PRPF2ATP-dependent RNA helicase #3DEAH-box protein 16pre-mRNA processing factor 2NMOASPRO2014PRP8