Target intelligence / Profile preview

DEAH-box helicase 9 (DHX9)

Target: DHX9
Molecular classification: Enzyme, Helicase, DEAD/DEAH-box superfamily, SF2 superfamily

Overview

DHX9 is a member of the DExH/D box family of RNA helicases. It is an NTP-dependent helicase with the ability to unwind both DNA and RNA duplexes as well as more complex nucleic acid structures. It plays central roles in multiple aspects of nucleic acid metabolism including RNA metabolism, DNA metabolism, transcriptional regulation, genome integrity, and innate immunity. High levels or dysregulation of DHX9 are associated with poor prognosis in several cancers, making it a promising target for oncology research.

Other names: ATP-dependent RNA helicase ARHA

Biological functions

RNA metabolismDNA metabolismTranscriptional regulationGenome integrityInnate immunityAntiviral responsemRNA splicingmRNA nuclear exportTranslation regulationmRNA decaymRNA transportmRNA storageDNA replicationCell cycle progressionDNA repair

Disease associations

Cancer

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