DEAH box polypeptide 29 pseudogene

DEAH-box polypeptide 29 pseudogene" (ENSG00000230987, LOC647132) refers to a *pseudogene*, which is a non-functional copy of a protein-coding gene—in this case, of the **DEAH-box helicase 29 (DHX29)** gene. Pseudogenes do not encode functional proteins, and by definition, lack the molecular function and druggability inherent to bona fide therapeutic targets[3]. The functional DHX29 gene product is an RNA helicase involved in translation initiation and possibly cancer cell proliferation, but the pseudogene neither encodes this protein nor assumes those biological roles[1][3]. Pseudogenes, while potentially involved in gene regulation or as disease biomarkers, are generally not considered therapeutic targets unless there is clear evidence to the contrary, which is lacking in this case[3][5]. Notes: - The term "pseudogene" indicates that ENSG00000230987 is distinguished from the functional DHX29 gene (ENSG00000067248), and does not itself encode a functional helicase or any protein[3]. - There is nothing to suggest this pseudogene is a therapeutic target, nor are there drugs or mechanisms of action relevant to it. - If the goal is to target the *functional* helicase (DHX29), information should reference the protein-coding gene, not its pseudogene[1]. Critical clarification: This target is a *pseudogene*, not a receptor, enzyme, transporter, or any canonical therapeutic target[3]. It is not actionable in the conventional sense used in drug discovery or biomedical therapeutics.

Other names

DEAH box polypeptide 29 pseudogeneLOC647132ENSG00000230987