Death-associated protein-like 1 (DAPL1)

Death-associated protein-like 1 (DAPL1) is a protein primarily involved in the regulation of epithelial cell homeostasis, differentiation, and apoptosis. It is highly expressed in tissues such as the retina/RPE, testis, and other epithelial linings. DAPL1 functions as a negative regulator of cell proliferation, and loss of DAPL1 leads to abnormal epithelial growth and disrupted tissue organization, as seen in knockout mouse models. In the testes, DAPL1 regulates steroidogenic pathways by influencing the expression of enzymes and factors controlling testosterone synthesis. Genomic variants in the DAPL1 locus are associated with increased susceptibility to age-related macular degeneration, especially in females. At present, DAPL1 is emerging as a disease-associated gene and a potential biomarker but is not yet a direct therapeutic target for drugs[1][3][4][5][6][7].

Other names

Early epithelial differentiation-associated proteinEEDAdeath associated protein like 1Death Associated Protein Like 1DAPL1