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Target intelligence / Profile preview
Death Receptor 3 (DR3)
- Target
- DR3
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
Death Receptor 3 (DR3), also known as TNFRSF25, is a type II transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It primarily mediates apoptosis and necroptosis, but more recognized functions are related to immune modulation and the regulation of T cell homeostasis, influencing inflammation and autoimmunity. Its ligand is TL1A. DR3 expression is highest in lymphoid tissues, including activated T cells and regulatory T cells.
- Other names
- TNFRSF25APO-3TRAMPWSL-1WSL-LRDDR3TR3Tumor Necrosis Factor Receptor Superfamily Member 25
02
Mechanism of action
TL1A binding initiates signaling cascades involving adaptor proteins like FADD/TRADD, leading to caspase activation (apoptosis) or RIPK1/RIPK3 activation (necroptosis). Can also activate NF-kB signaling.
03
Biological functions
ApoptosisNecroptosisImmune responseNF-kB activationT cell homeostasisCell differentiationSignal transduction
04
Disease associations
Inflammatory diseasesCancerAutoimmunity
05
Safety considerations
Potential for off-target effects on immune regulationComplex role in cancer progression may limit therapeutic applicability
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