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Target intelligence / Profile preview
Death receptor 4 (DR4)
- Target
- DR4
- Molecular classification
- Receptor, Tumor necrosis factor (TNF) receptor superfamily
01
Overview
Death receptor 4 is a key mediator linking extracellular apoptotic signals from immune surveillance or therapeutic agents directly into programmed cell death machinery within susceptible target cells—most notably cancerous ones—making it an important focus for research into targeted therapies against malignancies.
- Other names
- TRAIL receptor 1 (TRAILR1)Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
02
Mechanism of action
Agonistic antibodies bind to DR4, inducing receptor trimerization, recruitment of FADD and caspase-8, and subsequent activation of the caspase cascade leading to apoptosis.
03
Biological functions
ApoptosisSignal transductionImmune responseCell deathCytokine secretion
04
Disease associations
CancerImmunosuppression
05
Safety considerations
Limited efficacy of TRAIL-based therapies due to resistance mechanisms in tumors.Potential for off-target effects if not selective for cancer cells.Potential for inducing inflammatory cytokine secretion, leading to immunosuppression.
06
Interacting drugs
Agonistic antibodies targeting DR4
1 more in the full profile.
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