Target intelligence / Profile preview

Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase

Molecular classification: Enzyme

Overview

DprE2 (Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase) is an essential enzyme in Mycobacterium tuberculosis, functioning as part of the DprE1-DprE2 complex. This complex catalyzes the epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor for arabinogalactan synthesis, an essential component of the mycobacterial cell wall. DprE2 activity is dependent on its association with DprE1. Inhibition of DprE2 disrupts cell wall biosynthesis and is lethal to M. tuberculosis, making it a validated drug target. Pretomanid and delamanid inhibit DprE2.

Mechanism of action

Inhibition of DprE2 activity by forming an adduct with its cofactor (NAD) in the DprE1-DprE2 complex.

Biological functions

Epimerization in arabinogalactan biosynthesis

Disease associations

Infection

Interacting drugs

Pretomanid

1 more in the full profile.

Beyond the preview

Go deeper on Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase.

Explore the full profile