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Target intelligence / Profile preview
Decaprenylphosphoryl-beta-D-ribose oxidase (DprE1)
- Target
- DprE1
- Molecular classification
- Enzyme, Oxidase, Flavoenzyme
01
Overview
Decaprenylphosphoryl-beta-D-ribose oxidase (DprE1) is an essential flavoenzyme in *Mycobacterium tuberculosis*. It catalyzes a key step in the biosynthesis of decaprenyl-phospho-arabinose (DPA), an arabinose donor required for the synthesis of arabinogalactan and lipoarabinomannan. DprE1 functions with its partner protein DprE2 and is a validated drug target for tuberculosis.
- Other names
- Decaprenylphosphoryl-β-D-ribose oxidasedprE1
02
Mechanism of action
Inhibition of DprE1 prevents the synthesis of arabinogalactan and lipoarabinomannan, essential components of the mycobacterial cell wall.
03
Biological functions
Cell wall biosynthesisProduction of decaprenyl-phospho-arabinose (DPA)Epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA)
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Resistance development
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