Target intelligence / Profile preview

Decarboxylase (DC)

Target: DC
Molecular classification: Enzyme

Overview

Decarboxylase enzymes catalyze the removal of carboxyl groups (CO₂H) from acidic substrates, releasing carbon dioxide (CO₂) in the process. These enzymes are essential in various metabolic pathways, including amino acid metabolism, neurotransmitter synthesis, and carbohydrate processing. Many decarboxylases require pyridoxal phosphate (PLP) or pyruvate as cofactors. Inhibitors like carbidopa (targets aromatic L-amino acid decarboxylase) and DFMO (targets ornithine decarboxylase) are used therapeutically.

Other names: Carboxy-lyases

Mechanism of action

Inhibition of decarboxylation

Biological functions

CatalysisAmino acid metabolismNeurotransmitter synthesisCarbohydrate processingAcid resistance

Disease associations

Parkinson's diseaseCancer

Interacting drugs

Carbidopa

1 more in the full profile.

Beyond the preview

Go deeper on Decarboxylase (DC).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Decarboxylase (DC).

Explore the full profile