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Target intelligence / Profile preview
Decorin (DCN)
- Target
- DCN
- Molecular classification
- Small Leucine-Rich Proteoglycan (SLRP), Extracellular matrix protein, Proteoglycan
01
Overview
Decorin is a small leucine-rich proteoglycan (SLRP) that plays a critical role in the extracellular matrix (ECM) of connective tissues. It binds type I collagen fibrils, regulates growth factor activity (TGF-beta, etc.), antagonizes receptor tyrosine kinases (EGFR, HER2/ErbB2, Met/HGFR, VEGFR2/KDR/Flk1), inhibits angiogenesis, and promotes autophagy. It acts as a "guardian from the matrix," exerting potent antitumorigenic effects. Mutations or dysregulation are associated with connective tissue disorders and corneal dystrophy. Decorin has also been identified as a myokine.
02
Mechanism of action
Direct binding to receptor tyrosine kinases (EGFR, HER2/ErbB2, Met/HGFR, VEGFR2/KDR/Flk1), leading to transient activation followed by downregulation via internalization/degradation pathways. Sequestration of growth factors like TGF-beta, angiopoietins, HGF, and PDGF. Binding to myostatin.
03
Biological functions
Collagen assembly/fibrillogenesis regulationGrowth factor sequestration/modulationReceptor tyrosine kinase inhibitionAngiogenesis inhibitionAutophagy regulationMuscle hypertrophy promotion
04
Disease associations
CancerConnective tissue disordersCorneal dystrophy
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