Dedicator of cytokinesis family pseudogene

The dedicator of cytokinesis family pseudogene (ENSG00000248185/LOC100420027) is a segment of DNA highly similar to functional DOCK family genes, particularly dedicator of cytokinesis 9, but has accumulated mutations that prevent it from encoding a functional protein[1][2][6][11]. Pseudogenes like this often arise by gene duplication or retrotransposition events and are typically considered nonfunctional remnants[6][11]. While pseudogenes generally do not contribute protein products, some may have regulatory roles in gene expression—for example, acting as decoys for microRNAs or participating in competitive endogenous RNA networks that can indirectly affect their parental gene's expression[4][6]. In this case, the dedicator of cytokinesis family pseudogene does not encode an active guanine nucleotide exchange factor, and is not involved in canonical dedicator of cytokinesis (DOCK) protein signaling or diseases in a direct manner[1][2][6].

Other names

LOC100420027ENSG00000248185Dedicator of cytokinesis 9 pseudogene