Dedicator of cytokinesis protein 10 (DOCK10)

Dedicator of cytokinesis protein 10 (DOCK10) is a large (~240 kDa) cytoplasmic signaling protein and member of the DOCK-D subfamily of guanine nucleotide exchange factors (GEFs), characterized by DOCK homology domains (DHR1 and DHR2), and an N-terminal pleckstrin homology (PH) domain[1][3][8]. DOCK10 functions as a dual-specificity GEF, directly activating the small Rho GTPases Rac1 and Cdc42 by facilitating the exchange of GDP for GTP, a key event in intracellular signal transduction[2][3]. It is essential for dendritic spine morphogenesis in neurons and plays a role in B-cell activation, proliferation, and lymphopoiesis[2][3]. DOCK10 is expressed in a range of tissues including immune cells, brain, spleen, lung, and thymus, and is upregulated in activated B-lymphocytes and some carcinomas[1][4]. Elevated expression has been implicated in chronic lymphocytic leukemia and aggressive papillary thyroid carcinoma, and germline variation is linked to neurodevelopmental disorders[1][3][7]. No direct pharmacological inhibitors or approved interacting drugs are currently described for DOCK10.

Other names

Dedicator of cytokinesis 10Zizimin-3Zizimin3DRIP2KIAA0694Nbla10300dopamine receptor interacting protein 2ZIZ3

Guanine nucleotide exchange for Cdc42 and Rac1 (conversion of inactive GDP-bound GTPases to active GTP-bound form)