Dedicator of cytokinesis protein 6 (DOCK6)

Dedicator of cytokinesis protein 6 (DOCK6) is a cytoplasmic enzyme of the DOCK family that acts as an atypical guanine nucleotide exchange factor specifically for the small Rho-family GTPases CDC42 and RAC1. DOCK6 is crucial for actin cytoskeletal remodeling and signal transduction during embryonic development, particularly of the limbs, skull, and heart. By activating CDC42 and RAC1, DOCK6 facilitates neurite outgrowth and cellular migration. Mutations in DOCK6 disrupt these signaling pathways, leading to congenital disorders, most notably Adams-Oliver syndrome 2, a multisystem syndrome affecting the skin, limbs, and neurological development[1][3][4]. DOCK6 is classified molecularly as an enzyme (guanyl-nucleotide exchange factor), with its biological effects mediated through actin cytoskeleton regulation and intracellular signaling. Although no drugs currently target DOCK6 directly, its pivotal developmental role makes it a point of interest for future therapeutic interventions in congenital and possibly neurodevelopmental disorders.

Other names

KIAA1395ZIR1AOS2dedicator of cytokinesis protein 6DOCK6

For theoretical drugs targeting DOCK6, the mechanisms would include modulation or inhibition of GEF activity, thus altering CDC42 or RAC1 activation, which would impact actin remodeling and developmental signaling[1][3][4].