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Target intelligence / Profile preview
Defective in Cullin Neddylation 1 (DCUN1D1)
- Target
- DCUN1D1
- Molecular classification
- Adaptor Protein, Scaffold Protein, E3 Ubiquitin Ligase Complex Component
01
Overview
DCUN1D1 is a key component of the neddylation pathway, essential for activating cullin-RING ligases (CRLs) which regulate protein degradation via ubiquitination. It acts as an adaptor or scaffold that brings together components necessary for efficient neddylation, promoting transfer of NEDD8 from UBE2M-NEDD8 onto specific lysine residues on target cullins within CRLs. The *DCUN1D* gene is amplified in several cancer types—most notably squamous cell carcinomas—and may act as an oncogenic driver.
- Other names
- DCN1-like protein 1DCNL1SCCROSCROTes3RP42
02
Mechanism of action
Facilitates NEDD8 transfer to cullins within CRLs, relieving CAND1-mediated inhibition.
03
Biological functions
Protein neddylationRegulation of protein ubiquitinationCell cycle regulationApoptosis regulationSignal transduction
04
Disease associations
CancerSquamous cell carcinomaTumorigenesis
05
Safety considerations
Potential oncogenic driverAmplification in various cancers
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