Defective in cullin neddylation 1 domain containing 5 (DCUN1D5)

Defective in cullin neddylation 1 domain containing 5 (DCUN1D5) encodes a protein that is a member of the DCUN1/NEDD8 E3 ligase family, which facilitates neddylation—the covalent attachment of NEDD8 (a ubiquitin-like protein) to target cullin proteins[1][4]. This neddylation is crucial for activating cullin-RING E3 ubiquitin ligases, key regulators of protein degradation, cell cycle progression, and various cellular responses[1][8][10]. DCUN1D5 has been implicated in cell proliferation, DNA damage response, and anchorage-independent cell growth, and may play a role in cancer biology by influencing cullin-dependent protein turnover[1][4][9]. It primarily localizes to the nucleus and mitotic spindle[1][5]. There are no known approved drugs that directly target DCUN1D5, and it is not currently established as a principal drug target, but it may represent a potential vulnerability in cancer (as suggested by alternative names such as "squamous cell carcinoma-related oncogene 5")[1][4]. Note: While DCUN1D5 is a significant regulator in ubiquitin-proteasome system modulation and cancer biology, there are currently no direct pharmacologic inhibitors or clinical trials targeting this protein. It is a protein coding gene with growing importance in cancer research, but not a typical therapeutic target like a receptor, enzyme, or transporter[1][4][9].

Other names

DCNL5SCCRO5DCN1-like protein 5DCUN1 domain-containing protein 5Defective in cullin neddylation protein 1-like protein 5Squamous cell carcinoma-related oncogene 5MGC2714FLJ32431

Modulation of neddylation and cullin-RING E3 ubiquitin ligase activity