Defensin beta 110 (DEFB110)

Defensin beta 110 (DEFB110) is a member of the beta-defensin family, a group of small, cationic antimicrobial peptides produced in neutrophils and epithelial tissues. Beta-defensins, including DEFB110, possess broad-spectrum antimicrobial activity and form part of the innate immune response by disrupting microbial membranes through a pore-forming mechanism governed by their conserved cysteine-rich structure. In addition to direct microbicidal action, beta-defensins contribute to immune cell recruitment and modulation of immune responses, enhancing both innate and adaptive immunity. The expression of DEFB110, like other beta-defensins, is tightly clustered genomically, and their roles may extend from frontline defense (preventing infection in mucosal and epithelial surfaces) to more complex immune system functions. No drugs are currently known to target DEFB110 directly, and no disease-modifying roles or biomarker utilities unique to this isoform are established in the literature.

Other names

Defensin beta 110DEFB110DEFB10DEFB11DEFB111Beta-defensin 110Beta-defensin 10Beta-defensin 11Beta-defensin 111Defensin, beta 110Defensin, beta 111defensin, beta 110 locusbeta-defensin 110beta-defensin 10beta-defensin 11beta-defensin 111

Not applicable; DEFB110 acts as an endogenous antimicrobial peptide—not typically a direct therapeutic target for existing drugs