Deformed epidermal autoregulatory factor 1 transcription factor (DEAF1)

Deformed epidermal autoregulatory factor 1 transcription factor (DEAF1) is a multifunctional zinc finger, SAND and MYND domain-containing transcription factor[1][2][3]. It regulates transcription through direct DNA binding and protein-protein interactions. DEAF1 is crucial in embryonic development, central nervous system function (including serotonin receptor gene regulation), and immune response—especially in Drosophila, where it acts synergistically with other transcription factors to activate antimicrobial genes. In humans, DEAF1 modulates immune tolerance in lymph nodes and represses or enhances gene expression depending on the cellular context. Mutations in DEAF1 have been associated with cognitive disability, neurodevelopmental disorders, mood disease, and susceptibility to autoimmune conditions and osteoarthritis[2][3]. The gene exhibits alternative splicing resulting in multiple functional isoforms, and its activity is regulated by post-translational modifications such as phosphorylation[2].

Other names

NUDRSPNZMYND5MRD24SuppressinNuclear DEAF-1-related transcriptional regulatorZinc finger MYND domain-containing protein 5

Not applicable, as there are no known interacting drugs. Mechanistic research has focused on how DEAF1 regulates transcription rather than drug-mediated modulation[2].