Dehydrogenase enzyme family

Dehydrogenase enzyme family" is not a specific molecular target but a broad and heterogeneous class that includes many different enzyme families such as aldehyde dehydrogenases (ALDH), alcohol dehydrogenases (ADH), lactate dehydrogenases, and others. Each of these is itself a family (or superfamily) with specific subclasses and isoforms, each of which can be considered an individual target. For example, ALDHs are responsible for the oxidation of aldehydes to carboxylic acids and include at least 19 human genes divided into subclasses, each with distinct physiological and pathophysiological roles[1][2][3][4]. Similarly, the ADH family encompasses enzymes responsible for interconversion between alcohols and aldehydes, itself divided into several superfamilies and gene classes depending on sequence and functional similarity[6]. Thus, "dehydrogenase enzyme family" as a general label is too broad for precise targeting or structured use: it lacks the specificity required to map to a single gene, protein, or druggable target. Each distinct enzyme (e.g., Aldehyde dehydrogenase 2, Alcohol dehydrogenase 1B) would require its own structured entry.