Target intelligence / Profile preview

Dehydropeptidase I (DHP-I)

Target: DHP-I
Molecular classification: Enzyme, Hydrolase, Peptidase, Zinc-dependent metallopeptidase

Overview

Dehydropeptidase I (DHP-I), also known as membrane dipeptidase or DPEP1, is a zinc-dependent enzyme predominantly found in the kidneys. It plays a crucial role in the metabolism and hydrolysis of various dipeptides and certain antibiotics, most notably carbapenems such as imipenem. Inhibition of DHP-I by cilastatin is essential for maintaining the therapeutic efficacy of imipenem.

Other names: Membrane dipeptidaseDPEP1

Mechanism of action

Cilastatin inhibits dehydropeptidase I, preventing the renal metabolism of imipenem and increasing its systemic half-life and bioavailability.

Biological functions

Hydrolysis of dipeptidesMetabolism of carbapenem antibioticsRegulation of drug efficacy

Safety considerations

Dehydropeptidase I activity can reduce the efficacy of carbapenem antibiotics like imipenem.Requires co-administration of an inhibitor (cilastatin) to maintain therapeutic drug levels.

Interacting drugs

Imipenem

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