Target intelligence / Profile preview

Dehydrosqualene Synthase (None)

Target: None
Molecular classification: Enzyme, Prenyltransferase

Overview

Dehydrosqualene synthase (CrtM) is an enzyme found in *Staphylococcus aureus* that catalyzes the synthesis of dehydrosqualene, a precursor for staphyloxanthin. Staphyloxanthin is a carotenoid pigment contributing to bacterial virulence. CrtM is a target for antimicrobial drug development to combat *S. aureus* infections. It can also be used in metabolic engineering for the production of terpenoids.

Other names: CrtMSqualene synthase-like enzyme

Mechanism of action

Inhibition of dehydrosqualene synthesis, thereby blocking staphyloxanthin production

Biological functions

Carotenoid biosynthesisStaphyloxanthin synthesisTerpenoid synthesis

Disease associations

InfectionBacterial virulence

Interacting drugs

Lapaquistat acetate

2 more in the full profile.

Beyond the preview

Go deeper on Dehydrosqualene Synthase (None).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Dehydrosqualene Synthase (None).

Explore the full profile