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Deiodinase
- Molecular classification
- Enzyme, Selenocysteine-dependent enzyme, Peroxidase
01
Overview
Deiodinases are a family of enzymes that regulate thyroid hormone activity by catalyzing the removal of iodine atoms from thyroid hormones. This process is essential for both the activation and inactivation of these hormones, thereby controlling their bioavailability and physiological effects. There are three main types: DIO1, DIO2, and DIO3, each with distinct tissue distribution and substrate preferences. They play crucial roles in development, growth, metabolism, and tissue-specific responses to thyroid hormones.
- Other names
- Iodothyronine deiodinaseDIO1DIO2DIO3Type I deiodinaseType II deiodinaseType III deiodinaseD1D2D3
02
Mechanism of action
Catalyzes the removal of iodine atoms from thyroid hormones (T4 and T3)
03
Biological functions
Thyroid hormone activationThyroid hormone inactivationThyroid hormone homeostasisRegulation of metabolismRegulation of developmentRegulation of growthTissue-specific thyroid hormone action
04
Disease associations
HypothyroidismHyperthyroidismThyroid hormone resistance syndromesConsumptive hypothyroidism
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