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DEK proto-oncogene (DEK)

Target: DEK
Molecular classification: Chromatin-associated protein, DNA-binding protein, Transcription cofactor, Histone binding protein

Overview

DEK proto-oncogene (DEK) encodes a ubiquitously expressed nuclear chromatin protein involved in multiple nuclear processes, including altering DNA topology (such as positive supercoiling and catenation), regulating mRNA splice site selection, and acting as a hub for recruiting histones, histone modifiers, and chromatin remodeling factors[1][2][3][5]. DEK has a SAP domain for DNA binding and can interact with both cruciform and supercoiled DNA, modifying chromatin structure and potentially repressing or activating gene transcription[1][3][4]. Overexpression and chromosomal rearrangements of DEK are linked to various cancers, and autoantibodies to DEK have been identified in some autoimmune diseases[3][5].

Other names: Protein DEKD6S231EDEK oncogene (DNA binding)DEK proto-oncogeneprotein DEK

Biological functions

Chromatin modificationDNA supercoilingDNA bindingRegulation of mRNA splicingRegulation of DNA replication

Disease associations

CancerChemoresistanceAutoimmune disease (by autoantibody association)

Safety considerations

Potential oncogenic risk if dysregulatedpotential off-target effects if antagonized given its role in chromatin and RNA processing

Biomarkers

Autoantibodies to DEK (noted in association with certain diseases)

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