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Target intelligence / Profile preview
Delayed Rectifier Potassium Channel (n/a)
- Target
- n/a
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
The delayed rectifier potassium channel is a type of voltage-gated potassium (K+) channel that plays a critical role in repolarizing the membrane potential during the action potential in excitable cells, such as neurons and cardiac myocytes. These channels conduct outward K+ currents, which help restore the negative resting membrane potential after depolarization.
02
Mechanism of action
Outward K+ flow, membrane repolarization
03
Biological functions
Membrane repolarizationRegulation of action potential durationRegulation of action potential frequencyRegulation of heart rhythm
04
Disease associations
Long QT SyndromeShort QT SyndromeFamilial atrial fibrillationArrhythmia
05
Safety considerations
QT interval prolongationArrhythmias
06
Interacting drugs
hERG/Kv11.1 blockers
1 more in the full profile.
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