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Target intelligence / Profile preview
Deleted in Colorectal Carcinoma Protein (DCC)
- Target
- DCC
- Molecular classification
- Transmembrane receptor, Immunoglobulin superfamily
01
Overview
Deleted in colorectal carcinoma (DCC) is a transmembrane protein encoded by the DCC gene, located on chromosome 18q21 in humans. It functions as a tumor suppressor and as a receptor for netrin-1, playing a role in both cancer biology and neural development. DCC acts as a dependence receptor. In the absence of its ligand netrin-1, it induces apoptosis; when bound to netrin-1, it promotes cell survival. Loss or reduced expression of DCC is frequently observed in advanced colorectal cancers and other malignancies. DCC also functions as an axon guidance receptor critical for proper wiring of the brain and spinal cord.
02
Mechanism of action
Acts as a dependence receptor; induces apoptosis in the absence of netrin-1, promotes cell survival when bound to netrin-1.
03
Biological functions
Tumor suppressionAxon guidanceCell survivalApoptosis
04
Disease associations
CancerColorectal cancer
05
Safety considerations
Therapeutic strategies aimed at restoring DCC function need to consider its dependence receptor activity and potential for inducing apoptosis in normal cells.
06
Biomarkers
DCC protein expression (reduced or absent in colorectal cancer)LOH at chromosome 18q
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