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Target intelligence / Profile preview
Deleted in lymphocytic leukemia 1 (DLEU1)
- Target
- DLEU1
- Molecular classification
- Other (Long non-coding RNA, lncRNA)
01
Overview
Deleted in lymphocytic leukemia 1 (DLEU1) is a long non-coding RNA (lncRNA) gene, meaning it is transcribed into RNA that does not encode a protein. DLEU1 is located at chromosome 13q14, a region frequently deleted in chronic lymphocytic leukemia and some other hematologic and solid malignancies. As a lncRNA, DLEU1 is believed to regulate gene expression, cell proliferation, and apoptosis, although full mechanistic details remain under investigation. Aberrant expression of DLEU1 has been linked to cancer progression and may serve as a biomarker for disease diagnosis or prognosis[3][5]. No evidence suggests that DLEU1 is a classic therapeutic target such as a receptor, enzyme, or transporter. Rather, its importance is primarily in gene regulation and cancer biology as a non-coding RNA[3][5].
- Other names
- DLEU1Deleted in lymphocytic leukemia 1
02
Biological functions
Regulation of gene expressionpotential tumor suppressor activitypossible role in cell proliferation and apoptosis
03
Disease associations
Cancer (implicated in hematologic malignancies, especially chronic lymphocytic leukemia; associations also reported in other cancers)
04
Biomarkers
lncRNA expression may serve as a biomarker in cancer diagnosis/prognosis
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